Our research focuses on two core areas of Pathogenic Mechanisms of Prion-like Proteins in Neurodegeneration

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1. Prion-like Protein Dynamics in Neurodegeneration

• Elucidating the cell-to-cell transmission pathways of prion-like proteins (e.g. α-synuclein, tau)

• Dissecting the molecular mechanisms underlying intercellular propagation and induced neurotoxicity

• Exploring the impact of prion-like protein strains on disease phenotypes

• Examining neuroinflammatory processes triggered by prion-like protein pathology

• Investigating environmental factors that modulate prion-like protein aggregation and spreading

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2. Therapeutic Development for Prion Proteinopathies

• Developing nanobody-based therapies to disrupt prion-like protein aggregation and transmission

• Harnessing nanomaterials for improved targeting and delivery of therapeutics

• Screening and evaluating rejuvenator compounds to restore proteostasis and mitigate neurodegeneration

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Open Positions

We are seeking highly motivated researchers at all levels to join our team in unraveling the mechanisms of prion-like protein pathogenesis and developing novel therapeutics. Open positions include:

• Postdoctoral Fellows

• Graduate Students

• Undergraduate Students

• Visiting Scientists

If you are passionate about neurodegeneration research, please contact Dr. Xiaobo Mao to discuss opportunities.

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